sr1 [2018-09-12 10:44:02]

small regulatory RNA controlling AhrC expression, regulatory peptide

Locus: BSU14629

Isoelectric point: 4.00

Molecular weight: 4.00 kDa

Function: control of arginine metabolism and glycolysis

Product: small regulatory RNA, regulatory peptide

Essential: no

Synonyms: ykzW,sr1

Genomic Context

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Categories containing this gene/protein

• Metabolism → Amino acid/ nitrogen metabolism → Biosynthesis/ acquisition of amino acids → Biosynthesis/ acquisition of arginine
• Metabolism → Amino acid/ nitrogen metabolism → Utilization of amino acids → Utilization of arginine/ ornithine
• Groups of genes → NcRNA → Regulatory RNAs

Gene

Coordinates: 1,534,120 → 1,534,239

The RNA

Catalyzed reaction/ biological activity

• hybridizes to ahrC mRNA and inhibits AhrC translation PubMed

Interactions

• ahrC mRNA-sr1 RNA PubMed

Additional information

• Information on the structure of the RNA can be found in PubMed

Database entries

BsubCyc: BSU14629

UniProt: C0H410

The peptide

Catalyzed reaction/ biological activity:

• the peptide controls the stability of the cggR-gapA mRNA PubMed

Protein family:

• the peptide is conserved in bacilli

Interactions:

• GapA-Sr1 PubMed

Expression and Regulation

Operons

• Genes: sr1
  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

  Regulatory mechanism

  • CcpN: repression, in CcpN regulon

  Regulation

  • Repressed in the presence of glucose by CcpN PubMed

Biological materials

Mutant

• 168 ykzW::cat, available in Sabine Brantl's lab
• GP2210 (sr1::cat), available in Jörg Stülke's lab
• GP2215 (sr1::aphA3), available in Jörg Stülke's lab
• GP2216 (sr1::phleo), available in Jörg Stülke's lab
• BKE14629 (Δsr1::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATCTCTTATTCCCCATTTC, downstream forward: _UP4_TAAAAAAAAGCATGCGGCTT
• BKK14629 (Δsr1::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATCTCTTATTCCCCATTTC, downstream forward: _UP4_TAAAAAAAAGCATGCGGCTT

Labs working on this gene/protein

• Sabine Brantl, Bacterial Genetics, Friedrich-Schiller-University of Jena, Germany homepage

References

Reviews

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Original Publications

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